Nature Communications (May 2020)

KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

  • Michal Lipinski,
  • Rafael Muñoz-Viana,
  • Beatriz del Blanco,
  • Angel Marquez-Galera,
  • Juan Medrano-Relinque,
  • José M. Caramés,
  • Andrzej A. Szczepankiewicz,
  • Jordi Fernandez-Albert,
  • Carmen M. Navarrón,
  • Roman Olivares,
  • Grzegorz M. Wilczyński,
  • Santiago Canals,
  • Jose P. Lopez-Atalaya,
  • Angel Barco

DOI
https://doi.org/10.1038/s41467-020-16246-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.