Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Doan C. Nguyen; Swetha Garimalla; Haopeng Xiao; Shuya Kyu; Igor Albizua; Jacques Galipeau; Kuang-Yueh Chiang; Edmund K. Waller; Ronghu Wu; Greg Gibson; James Roberson; Frances E. Lund; Troy D. Randall; Iñaki Sanz; F. Eun-Hyung Lee

doi:10.1038/s41467-018-05853-7

Nature Communications (Sep 2018)

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Doan C. Nguyen,
Swetha Garimalla,
Haopeng Xiao,
Shuya Kyu,
Igor Albizua,
Jacques Galipeau,
Kuang-Yueh Chiang,
Edmund K. Waller,
Ronghu Wu,
Greg Gibson,
James Roberson,
Frances E. Lund,
Troy D. Randall,
Iñaki Sanz,
F. Eun-Hyung Lee

Affiliations

Doan C. Nguyen: Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University
Swetha Garimalla: School of Biological Sciences, Georgia Institute of Technology
Haopeng Xiao: School of Chemistry and Biochemistry, Georgia Institute of Technology
Shuya Kyu: Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University
Igor Albizua: Department of Human Genetics, Emory University
Jacques Galipeau: Department of Medicine & University of Wisconsin Carbone Cancer Center, University of Wisconsin in Madison
Kuang-Yueh Chiang: Division of Hematology & Oncology, University of Toronto
Edmund K. Waller: Pediatrics & Hematology/Oncology, Emory University
Ronghu Wu: School of Chemistry and Biochemistry, Georgia Institute of Technology
Greg Gibson: School of Biological Sciences, Georgia Institute of Technology
James Roberson: Department of Orthopedics, Emory University
Frances E. Lund: Department of Microbiology, University of Alabama at Birmingham
Troy D. Randall: Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham
Iñaki Sanz: Division of Rheumatology, Emory University
F. Eun-Hyung Lee: Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University

DOI: https://doi.org/10.1038/s41467-018-05853-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, APRIL, and hypoxic conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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