Nature Communications (Jul 2016)

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

  • Hagoon Jang,
  • Gha Young Lee,
  • Christopher P. Selby,
  • Gung Lee,
  • Yong Geun Jeon,
  • Jae Ho Lee,
  • Kenneth King Yip Cheng,
  • Paul Titchenell,
  • Morris J. Birnbaum,
  • Aimin Xu,
  • Aziz Sancar,
  • Jae Bum Kim

DOI
https://doi.org/10.1038/ncomms12180
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose production by promoting proteasomal degradation of Foxo1.