Nature Communications (Apr 2020)
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
- Philip E. D. Chung,
- Deena M. A. Gendoo,
- Ronak Ghanbari-Azarnier,
- Jeff C. Liu,
- Zhe Jiang,
- Jennifer Tsui,
- Dong-Yu Wang,
- Xiao Xiao,
- Bryan Li,
- Adrian Dubuc,
- David Shih,
- Marc Remke,
- Ben Ho,
- Livia Garzia,
- Yaacov Ben-David,
- Seok-Gu Kang,
- Sidney Croul,
- Benjamin Haibe-Kains,
- Annie Huang,
- Michael D. Taylor,
- Eldad Zacksenhaus
Affiliations
- Philip E. D. Chung
- Toronto General Research Institute, University Health Network
- Deena M. A. Gendoo
- Centre for Computational Biology, Institute of Cancer and Genomic Sciences, University of Birmingham
- Ronak Ghanbari-Azarnier
- Toronto General Research Institute, University Health Network
- Jeff C. Liu
- Toronto General Research Institute, University Health Network
- Zhe Jiang
- Toronto General Research Institute, University Health Network
- Jennifer Tsui
- Toronto General Research Institute, University Health Network
- Dong-Yu Wang
- Toronto General Research Institute, University Health Network
- Xiao Xiao
- Toronto General Research Institute, University Health Network
- Bryan Li
- Department of Laboratory Medicine & Pathobiology, University of Toronto
- Adrian Dubuc
- Department of Laboratory Medicine & Pathobiology, University of Toronto
- David Shih
- Department of Laboratory Medicine & Pathobiology, University of Toronto
- Marc Remke
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Ben Ho
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Livia Garzia
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Yaacov Ben-David
- The Key laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences
- Seok-Gu Kang
- Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine
- Sidney Croul
- Department of Pathology & Laboratory Medicine, Division of Anatomical Pathology, Dalhousie University
- Benjamin Haibe-Kains
- Princess Margaret Cancer Centre, University Health Network
- Annie Huang
- Department of Laboratory Medicine & Pathobiology, University of Toronto
- Michael D. Taylor
- Department of Laboratory Medicine & Pathobiology, University of Toronto
- Eldad Zacksenhaus
- Toronto General Research Institute, University Health Network
- DOI
- https://doi.org/10.1038/s41467-020-15585-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-clinical model.
