Nature Communications (Jun 2021)
Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities
- Changhon Lee,
- Ravi Verma,
- Seohyun Byun,
- Eun-Ji Jeun,
- Gi-Cheon Kim,
- Suyoung Lee,
- Hye-Ji Kang,
- Chan Johng Kim,
- Garima Sharma,
- Abhishake Lahiri,
- Sandip Paul,
- Kwang Soon Kim,
- Dong Soo Hwang,
- Yoichiro Iwakura,
- Immacolata Speciale,
- Antonio Molinaro,
- Cristina De Castro,
- Dipayan Rudra,
- Sin-Hyeog Im
Affiliations
- Changhon Lee
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Ravi Verma
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Seohyun Byun
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Eun-Ji Jeun
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Gi-Cheon Kim
- Department of Microbiology and Immunology, Yonsei University College of Medicine
- Suyoung Lee
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Hye-Ji Kang
- Advanced convergence, Handong Global University
- Chan Johng Kim
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Garima Sharma
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Abhishake Lahiri
- Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology
- Sandip Paul
- Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology
- Kwang Soon Kim
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Dong Soo Hwang
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Yoichiro Iwakura
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Immacolata Speciale
- Department of Agricultural Sciences, University of Napoli
- Antonio Molinaro
- Task Force on Microbiome Studies, University of Naples Federico II
- Cristina De Castro
- Department of Agricultural Sciences, University of Napoli
- Dipayan Rudra
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- Sin-Hyeog Im
- Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
- DOI
- https://doi.org/10.1038/s41467-021-23929-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Yeast form part of the host microbiome with known impact on host immunity. Here the authors identify and investigate the impact of commensal yeast-derived polysaccharides in modulating host inflammation, and show its potential for inhibiting inflammation in a number of models of inflammatory diseases.
