Heparin-induced thrombocytopenia occurring early after living donor liver transplantation: a case report

Abstract

Abstract. Background. Thrombocytopenia commonly occurs early after liver transplantation. Heparin, usually administered as anticoagulant therapy for thrombosis, a common complication after liver transplantation, may cause heparin-induced thrombocytopenia. Heparin-induced thrombocytopenia is a rare but life-threatening complication, and its diagnosis after liver transplantation is challenging. Case presentation. We report a case of heparin-induced thrombocytopenia after living donor liver transplantation with a good outcome because of early diagnosis and discontinuation of heparin. After liver transplantation, the platelet count usually reaches a nadir on postoperative days 3–5 and gradually recovers. In contrast, heparin-induced thrombocytopenia typically occurs 5–10 days after heparin administration; therefore, if heparin is started intraoperatively, then thrombocytopenia will occur on postoperative days 5–10. Conclusion. Monitoring the trend and timing of thrombocytopenia and detailed examination for thrombosis may help confirm the diagnosis of heparin-induced thrombocytopenia in the early stage after liver transplantation.