Nature Communications (Feb 2023)
Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance
- Mei Lin,
- Xiao-Long Zhang,
- Rui You,
- You-Ping Liu,
- Hong-Min Cai,
- Li-Zhi Liu,
- Xue-Fei Liu,
- Xiong Zou,
- Yu-Long Xie,
- Ru-Hai Zou,
- Yi-Nuan Zhang,
- Rui Sun,
- Wei-Yi Feng,
- Hai-Yan Wang,
- Gui-Hua Tao,
- Hao-Jiang Li,
- Wen-Jie Huang,
- Chao Zhang,
- Pei-Yu Huang,
- Jin Wang,
- Qi Zhao,
- Qi Yang,
- Hong-Wan Zhang,
- Ting Liu,
- Hui-Feng Li,
- Xiao-Bing Jiang,
- Jun Tang,
- Yang-Kui Gu,
- Tao Yu,
- Zhi-Qiang Wang,
- Lin Feng,
- Tie-Bang Kang,
- Zhi-Xiang Zuo,
- Ming-Yuan Chen
Affiliations
- Mei Lin
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Xiao-Long Zhang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Rui You
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- You-Ping Liu
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Hong-Min Cai
- School of Computer Science and Engineering, South China University of Technology
- Li-Zhi Liu
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Xue-Fei Liu
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Xiong Zou
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Yu-Long Xie
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Ru-Hai Zou
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Yi-Nuan Zhang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Rui Sun
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Wei-Yi Feng
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Hai-Yan Wang
- College of Mathematics and Informatics, South China Agricultural University
- Gui-Hua Tao
- School of Computer Science and Engineering, South China University of Technology
- Hao-Jiang Li
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Wen-Jie Huang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Chao Zhang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Pei-Yu Huang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Jin Wang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Qi Zhao
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Qi Yang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Hong-Wan Zhang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Ting Liu
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Hui-Feng Li
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Xiao-Bing Jiang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Jun Tang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Yang-Kui Gu
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Tao Yu
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Zhi-Qiang Wang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- Lin Feng
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Tie-Bang Kang
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Zhi-Xiang Zuo
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Ming-Yuan Chen
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-023-35995-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
It is critical to understand the factors that are associated with nasopharyngeal carcinoma (NPC) progression, metastasis and response to therapy. Here, the authors analyse primary and metastatic NPC samples using bulk and single-cell sequencing, and find two distinct evolutionary routes that lead to metastasis.
