Role of gut microbiota in type 2 diabetes pathophysiology
Manoj Gurung,
Zhipeng Li,
Hannah You,
Richard Rodrigues,
Donald B Jump,
Andrey Morgun,
Natalia Shulzhenko
Affiliations
Manoj Gurung
Colleges of Veterinary Medicine, Oregon State University, 700 SW 30th street, Corvallis, OR, 97331, USA
Zhipeng Li
Colleges of Veterinary Medicine, Oregon State University, 700 SW 30th street, Corvallis, OR, 97331, USA
Hannah You
Colleges of Veterinary Medicine, Oregon State University, 700 SW 30th street, Corvallis, OR, 97331, USA
Richard Rodrigues
Colleges of Pharmacy, Oregon State University, 160 SW 26th street, Corvallis, OR 97331, USA
Donald B Jump
Colleges of Public Health, Oregon State University, 160 SW 26th street, Corvallis, OR 97331, USA
Andrey Morgun
Colleges of Pharmacy, Oregon State University, 160 SW 26th street, Corvallis, OR 97331, USA; Corresponding authors: 1601 SW Jefferson Street, Corvallis, OR 97331, USA.
Natalia Shulzhenko
Colleges of Veterinary Medicine, Oregon State University, 700 SW 30th street, Corvallis, OR, 97331, USA; Corresponding authors: 1601 SW Jefferson Street, Corvallis, OR 97331, USA.
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D. Keywords: Type 2 diabetes, Microbiota, 16S rRNA, Metagenomics, Insulin resistance
