Zhongguo youzhi (Jun 2024)
苏尼特羊尾油对自发性高血压大鼠机能代谢的影响Effect of sunite sheep tail fat on functional metabolism in spontaneously hypertensive rats
Abstract
旨在为羊尾油对动物健康效应的研究提供基础数据，创建了自发性高血压大鼠（SHR）模型，将8周龄SHR分为试验组苏尼特羊尾油组（Y组）、阴性对照大豆油组（D组）、阳性对照菜籽油组（C组）和芥花油组（J组），并分别饲喂添加10%相应油脂的饲料，记录日摄食量，每周测量血压，饲喂14周后解剖采血,摘取肝脏，检测血清血脂水平、肝脏功能指标和肝脏病理学特征。结果表明：第14周时，Y组雌、雄SHR日摄食量显著高于对照组(p<0.05)，血压显著低于对照组（p<0.05）；Y组SHR血清中总胆固醇、甘油三酯和低密度脂蛋白胆固醇含量以及谷丙转氨酶、谷草转氨酶、γ-谷氨酰转移酶和乳酸脱氢酶活性显著低于对照组（p<0.05），而高密度脂蛋白胆固醇含量显著高于对照组(p<0.05)；C组和J组SHR肝脏病变严重，Y组SHR肝脏组织未出现病变。综上，与对照组植物油相比，苏尼特羊尾油具有缓和SHR血压升高、有效改善血脂和肝脏机能作用，是具有良好健康效应的动物性油脂。To provide basic data for investigating the effects of sheep tail fat on animal health, a spontaneously hypertensive rat (SHR) model was developed. SHRs with eight weeks of age were allocated into four groups: the experimental group with sunite sheep tail fat (Y group), a negative control group with soybean oil (D group), and two positive control groups with rapeseed oil (C group) and mustard oil (J group), respectively. These groups were provided with diets incorporating 10% of the respective oils. Feed intake was monitored daily, and blood pressure was measured weekly. After a 14-week feeding period, the SHRs were euthanized for collection of blood and liver to assess serum lipid profiles, liver function markers and pathological features. The results showed that the daily feed intake of female and male SHRs at week 14 in the Y groups was significantly higher than that of the control group (p<0.05), while the blood pressure was lower than that of the control group (p<0.05). The total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, along with markers of liver function such as ALT, AST, γ-glutamyl transferase and lactate dehydrogenase were significantly reduced in the Y group compared with control groups (p<0.05). Conversely, high-density lipoprotein cholesterol levels were significantly elevated (p<0.05). Notably, liver tissues from the Y group did not show pathological alterations, in contrast to the significant hepatic lesions observed in the C and J groups. In conclusion, sunite sheep tail fat demonstrates a capacity to moderate blood pressure elevation and enhance blood lipid and liver functions in SHRs, positioning it as an animal fat with potential health benefits.
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