Nature Communications (Nov 2021)

Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo

  • David Lähnemann,
  • Johannes Köster,
  • Ute Fischer,
  • Arndt Borkhardt,
  • Alice C. McHardy,
  • Alexander Schönhuth

DOI
https://doi.org/10.1038/s41467-021-26938-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors. Here, the authors describe ProSolo, a model for calling single nucleotide variants with control over the false discovery rate.