Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing Salmonella enterica serovar Typhimurium isolated from a case of fatal burn wound infection

Abstract

Kokila Banerjee,1 Priyadharshini Sekar,2 Padma Krishnan,2 Alice Rebecca Wattam,3 Subhendu Roy,1 John P Hays,4 Godfred A Menezes5 1Department of Microbiology, Drs Tribedi and Roy Diagnostic Laboratory, Kolkata, India; 2Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai, India; 3Network Dynamics and Simulation Science Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, VA, USA; 4Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands; 5Department of Medical Microbiology and Immunology, RAK College of Medical Sciences, RAK Medical and Health Sciences University (RAKMHSU), Ras Al Khaimah, UAE Abstract: Salmonella species are frequently associated with gastrointestinal infections such as diarrhea. However, extraintestinal Salmonella infections, including burn infections, have been described. Here, we report the first case of a carbapenem-resistant and metallo-β-lactamase (New Delhi metallo-β-lactamase), extended-spectrum β-lactamase (SHV-12), and AmpC β-lactamase (CMY-4) coproducing Salmonella Typhimurium isolated from a fatal case of burn wound infection. The publication highlights the necessity for the rational use of antibiotics (particularly the rational use of last-resort antibiotics such as carbapenems) in hospitals and burn units, as well as the need for systematic screening of Salmonella spp. (including Salmonella enterica serovar Typhimurium) for resistance to carbapenem antibiotics. Keywords: Salmonella, metallo-β-lactamase, extended-spectrum and AmpC β-lactamase, coproduction, whole genome sequencing, fatal burn wound

Keywords

• Salmonella
• Metallo- β-lactamase
• Extended spectrum and AmpC β-lactamase
• co-production
• whole genome sequencing
• fatal burn wound