Musicogenic reflex seizure with positive antiglutamic decarboxylase antibody: A case report

Abstract

Abstract The association of musicogenic epilepsy (ME) with antibodies against glutamic decarboxylase (GAD) supports autoimmune workups for these patients. No appropriate treatment has been established for ME; therefore, immunotherapy should be considered for patients who become drug‐resistant. The connection between neurological manifestations and antibodies against GAD, a rate‐limiting enzyme that helps create the inhibitory neurotransmitter gamma‐aminobutyric acid, has been well established. Furthermore, a strong correlation has been found between ME and the temporal lobe. However, its connection with anti‐GAD antibodies is still unclear. This paper reports on a 50‐year‐old right‐handed female who has had ME symptoms for 14 years and been found to be anti‐GAD antibody–positive. Therefore, we will elaborate on the relation between ME and anti‐GAD antibodies.

Keywords

• GAD‐Ab
• musicogenic epilepsy
• temporal lobe