Nature Communications (Oct 2017)

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

  • Jason Ziveri,
  • Fabiola Tros,
  • Ida Chiara Guerrera,
  • Cerina Chhuon,
  • Mathilde Audry,
  • Marion Dupuis,
  • Monique Barel,
  • Sarantis Korniotis,
  • Simon Fillatreau,
  • Lara Gales,
  • Edern Cahoreau,
  • Alain Charbit

DOI
https://doi.org/10.1038/s41467-017-00889-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.