Nature Communications (Oct 2020)

Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

  • Justin B. Moroney,
  • Anusha Vasudev,
  • Alexander Pertsemlidis,
  • Hong Zan,
  • Paolo Casali

DOI
https://doi.org/10.1038/s41467-020-19242-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination. Here the authors describe, using transcriptional and epigenetic data from human memory B cells and integrated multi-omics analyses, the differentiation regulation and trajectory of IgG+, IgA+ and IgD+ memory B cells.