Communications Biology (Dec 2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
- Karoline B. Rypdal,
- A. Olav Melleby,
- Emma L. Robinson,
- Jia Li,
- Sheryl Palmero,
- Deborah E. Seifert,
- Daniel Martin,
- Catelyn Clark,
- Begoña López,
- Kristine Andreassen,
- Christen P. Dahl,
- Ivar Sjaastad,
- Theis Tønnessen,
- Mathis K. Stokke,
- William E. Louch,
- Arantxa González,
- Stephane Heymans,
- Geir Christensen,
- Suneel S. Apte,
- Ida G. Lunde
Affiliations
- Karoline B. Rypdal
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- A. Olav Melleby
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Emma L. Robinson
- Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases
- Jia Li
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Sheryl Palmero
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Deborah E. Seifert
- Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute
- Daniel Martin
- Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute
- Catelyn Clark
- Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute
- Begoña López
- Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA
- Kristine Andreassen
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Christen P. Dahl
- Department of Cardiology, Oslo University Hospital Rikshospitalet
- Ivar Sjaastad
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Theis Tønnessen
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Mathis K. Stokke
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- William E. Louch
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Arantxa González
- Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA
- Stephane Heymans
- Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases
- Geir Christensen
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Suneel S. Apte
- Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute
- Ida G. Lunde
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- DOI
- https://doi.org/10.1038/s42003-022-04361-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
The role of ADAMTSL3 in heart pathology and cardiac disease is investigated with Adamtsl3-deficient mice using CRISPR-Cas9 gene editing.
