Nature Communications (Oct 2016)
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
- Ryan Kolb,
- Liem Phan,
- Nicholas Borcherding,
- Yinghong Liu,
- Fang Yuan,
- Ann M. Janowski,
- Qing Xie,
- Kathleen R. Markan,
- Wei Li,
- Matthew J. Potthoff,
- Enrique Fuentes-Mattei,
- Lesley G. Ellies,
- C. Michael Knudson,
- Mong-Hong Lee,
- Sai-Ching J. Yeung,
- Suzanne L. Cassel,
- Fayyaz S. Sutterwala,
- Weizhou Zhang
Affiliations
- Ryan Kolb
- Department of Pathology, University of Iowa Carver College of Medicine
- Liem Phan
- University of Texas Graduate School of Biomedical Sciences at Houston
- Nicholas Borcherding
- Department of Pathology, University of Iowa Carver College of Medicine
- Yinghong Liu
- Department of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University
- Fang Yuan
- Department of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University
- Ann M. Janowski
- Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine
- Qing Xie
- Department of Pathology, University of Iowa Carver College of Medicine
- Kathleen R. Markan
- Department of Pharmacology, University of Iowa Carver College of Medicine
- Wei Li
- Department of Pathology, University of Iowa Carver College of Medicine
- Matthew J. Potthoff
- Department of Pharmacology, University of Iowa Carver College of Medicine
- Enrique Fuentes-Mattei
- Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center
- Lesley G. Ellies
- Department of Pathology, University of California, San Diego
- C. Michael Knudson
- Department of Pathology, University of Iowa Carver College of Medicine
- Mong-Hong Lee
- University of Texas Graduate School of Biomedical Sciences at Houston
- Sai-Ching J. Yeung
- University of Texas Graduate School of Biomedical Sciences at Houston
- Suzanne L. Cassel
- Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine
- Fayyaz S. Sutterwala
- Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine
- Weizhou Zhang
- Department of Pathology, University of Iowa Carver College of Medicine
- DOI
- https://doi.org/10.1038/ncomms13007
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis.
