Magnetic Resonance Diffusion-Weighted Imaging for Detecting Fundal Intracholecystic Papillary Neoplasm inside Rokitansky-Aschoff Sinuses: A Comparison of Two Cases and a Literature Review
Francesco Sanvito,
Anna Gallotti,
Lorenzo Cobianchi,
Alessandro Vanoli,
Nicholas S. Cho,
Lorenzo Preda
Affiliations
Francesco Sanvito
Unit of Radiology, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Anna Gallotti
Department of Radiology, I.R.C.C.S. Policlinico San Matteo, 27100 Pavia, Italy
Lorenzo Cobianchi
Department of General Surgery, University of Pavia and I.R.C.C.S. Policlinico San Matteo, 27100 Pavia, Italy
Alessandro Vanoli
Unit of Anatomic Pathology, Department of Molecular Medicine, University of Pavia and I.R.C.C.S. Policlinico San Matteo, 27100 Pavia, Italy
Nicholas S. Cho
Center for Computer Vision and Imaging Biomarkers, UCLA Brain Tumor Imaging Laboratory (BTIL), University of California Los Angeles, Los Angeles, CA 90024, USA
Lorenzo Preda
Unit of Radiology, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Rokitansky-Aschoff sinuses (RAS) are a common imaging finding in gallbladder adenomyomatosis (ADM), often presenting as fundal cystic spaces. Intracholecystic papillary neoplasm (ICPN) is a relatively uncommon pre-invasive tumor of the gallbladder epithelium that rarely involves RAS mucosa. We compare two cases that showed similar fundal cystic spaces resembling RAS, in which Magnetic Resonance Diffusion-Weighted Imaging (MR-DWI) was valuable for detecting (or ruling out) an underlying malignant ICPN. Evidence from the literature overall supports the role of MR-DWI for detecting intracholecystic malignant tissue.
