Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids

Jonathan W. Lehmann; Ian T. Crouch; Daniel J. Blair; Melanie Trobe; Pulin Wang; Junqi Li; Martin D. Burke

doi:10.1038/s41467-019-09249-z

Nature Communications (Mar 2019)

Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids

Jonathan W. Lehmann,
Ian T. Crouch,
Daniel J. Blair,
Melanie Trobe,
Pulin Wang,
Junqi Li,
Martin D. Burke

Affiliations

Jonathan W. Lehmann: Department of Chemistry, University of Illinois at Urbana-Champaign
Ian T. Crouch: Department of Chemistry, University of Illinois at Urbana-Champaign
Daniel J. Blair: Department of Chemistry, University of Illinois at Urbana-Champaign
Melanie Trobe: Department of Chemistry, University of Illinois at Urbana-Champaign
Pulin Wang: Department of Chemistry, University of Illinois at Urbana-Champaign
Junqi Li: Department of Chemistry, University of Illinois at Urbana-Champaign
Martin D. Burke: Department of Chemistry, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-019-09249-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Despite the progress in C(sp3) cross-coupling reactions, full control over the stereochemistry remains a challenge. Here, the authors show that phosphine-containing axially shielded Pd(II) complexes enable Suzuki-Miyaura cross-couplings of unactivated C(sp3) boronic acids with perfect stereoretention.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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