Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Catherine Jensen Peña; Milo Smith; Aarthi Ramakrishnan; Hannah M. Cates; Rosemary C. Bagot; Hope G. Kronman; Bhakti Patel; Austin B. Chang; Immanuel Purushothaman; Joel Dudley; Hirofumi Morishita; Li Shen; Eric J. Nestler

doi:10.1038/s41467-019-13085-6

Nature Communications (Nov 2019)

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Catherine Jensen Peña,
Milo Smith,
Aarthi Ramakrishnan,
Hannah M. Cates,
Rosemary C. Bagot,
Hope G. Kronman,
Bhakti Patel,
Austin B. Chang,
Immanuel Purushothaman,
Joel Dudley,
Hirofumi Morishita,
Li Shen,
Eric J. Nestler

Affiliations

Catherine Jensen Peña: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Milo Smith: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Aarthi Ramakrishnan: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Hannah M. Cates: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Rosemary C. Bagot: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Hope G. Kronman: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Bhakti Patel: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Austin B. Chang: Princeton Neuroscience Institute, Princeton University
Immanuel Purushothaman: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Joel Dudley: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Hirofumi Morishita: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Li Shen: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Eric J. Nestler: Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-019-13085-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult mice after early life and/or adult stress

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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