Nature Communications (Aug 2018)
A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
- Anzhong Li,
- Jingyou Yu,
- Mijia Lu,
- Yuanmei Ma,
- Zayed Attia,
- Chao Shan,
- Miaoge Xue,
- Xueya Liang,
- Kelsey Craig,
- Nirajkumar Makadiya,
- Jennifer J. He,
- Ryan Jennings,
- Pei-Yong Shi,
- Mark E. Peeples,
- Shan-Lu Liu,
- Prosper N. Boyaka,
- Jianrong Li
Affiliations
- Anzhong Li
- Department of Veterinary Biosciences, The Ohio State University
- Jingyou Yu
- Department of Veterinary Biosciences, The Ohio State University
- Mijia Lu
- Department of Veterinary Biosciences, The Ohio State University
- Yuanmei Ma
- Department of Veterinary Biosciences, The Ohio State University
- Zayed Attia
- Department of Veterinary Biosciences, The Ohio State University
- Chao Shan
- Department of Biochemistry & Molecular Biology, Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch
- Miaoge Xue
- Department of Veterinary Biosciences, The Ohio State University
- Xueya Liang
- Department of Veterinary Biosciences, The Ohio State University
- Kelsey Craig
- Department of Veterinary Biosciences, The Ohio State University
- Nirajkumar Makadiya
- Department of Veterinary Biosciences, The Ohio State University
- Jennifer J. He
- Department of Veterinary Biosciences, The Ohio State University
- Ryan Jennings
- Department of Veterinary Biosciences, The Ohio State University
- Pei-Yong Shi
- Department of Biochemistry & Molecular Biology, Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch
- Mark E. Peeples
- Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
- Shan-Lu Liu
- Department of Veterinary Biosciences, The Ohio State University
- Prosper N. Boyaka
- Department of Veterinary Biosciences, The Ohio State University
- Jianrong Li
- Department of Veterinary Biosciences, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-018-05276-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protection in mice.
