Genetically-engineered T cells to treat viral hepatitis-associated liver cancer: is it possible?

Abstract

Adoptive T-cell immunotherapy is gaining credibility and popularity as a potential tool to cure cancer. Genetic engineering utilization of this therapeutic mode currently comes in the forms of chimeric antigen receptor- and T-cell receptor-engineered T cells. This short review focuses on opportunities to use engineered T cells to treat viral hepatitis-associated hepatocellular carcinoma.

Keywords

• adoptive T-cell immunotherapy
• chimeric antigen receptor
• T-cell receptor
• viral hepatitis
• hepatocellular carcinoma