Effects of Berberine on the Gastrointestinal Microbiota

Lichao Zhang; Lichao Zhang; Lichao Zhang; Xiaoying Wu; Xiaoying Wu; Xiaoying Wu; Ruibing Yang; Fang Chen; Yao Liao; Yao Liao; Yao Liao; Zifeng Zhu; Zifeng Zhu; Zifeng Zhu; Zhongdao Wu; Zhongdao Wu; Zhongdao Wu; Xi Sun; Xi Sun; Xi Sun; Lifu Wang; Lifu Wang; Lifu Wang

doi:10.3389/fcimb.2020.588517

Frontiers in Cellular and Infection Microbiology (Feb 2021)

Effects of Berberine on the Gastrointestinal Microbiota

Lichao Zhang,
Lichao Zhang,
Lichao Zhang,
Xiaoying Wu,
Xiaoying Wu,
Xiaoying Wu,
Ruibing Yang,
Fang Chen,
Yao Liao,
Yao Liao,
Yao Liao,
Zifeng Zhu,
Zifeng Zhu,
Zifeng Zhu,
Zhongdao Wu,
Zhongdao Wu,
Zhongdao Wu,
Xi Sun,
Xi Sun,
Xi Sun,
Lifu Wang,
Lifu Wang,
Lifu Wang

Affiliations

Lichao Zhang: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Lichao Zhang: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Lichao Zhang: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
Xiaoying Wu: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Xiaoying Wu: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Xiaoying Wu: Department of Gastroenterology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Ruibing Yang: Medical Department, Xizang Minzu University, Xianyang, China
Fang Chen: School of Medicine, South China University of Technology, Guangzhou, China
Yao Liao: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Yao Liao: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Yao Liao: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
Zifeng Zhu: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Zifeng Zhu: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Zifeng Zhu: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
Zhongdao Wu: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Zhongdao Wu: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Zhongdao Wu: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
Xi Sun: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Xi Sun: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Xi Sun: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
Lifu Wang: Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
Lifu Wang: Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Lifu Wang: Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China

DOI: https://doi.org/10.3389/fcimb.2020.588517
Journal volume & issue: Vol. 10

Abstract

Read online

The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regarding berberine use in cardiovascular, gastrointestinal, and endocrine diseases. Berberine elicits clinical benefits at standard doses and has low toxicity. The mechanism underlying the role of berberine in lipid‐lowering and insulin resistance is incompletely understood, but one of the possible mechanisms is related to its effect on the gastrointestinal microbiota. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences, Science Direct) was used to identify the role of the gastrointestinal microbiota in the berberine treatment. The aim of this review was to summarize the pharmacologic effects of berberine on animals and humans by regulation of the gastrointestinal microbiota.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

About the journal

Abstract

Keywords