Nature Communications (Jan 2017)

Wafer-scale integration of sacrificial nanofluidic chips for detecting and manipulating single DNA molecules

  • Chao Wang,
  • Sung-Wook Nam,
  • John M. Cotte,
  • Christopher V. Jahnes,
  • Evan G. Colgan,
  • Robert L. Bruce,
  • Markus Brink,
  • Michael F. Lofaro,
  • Jyotica V. Patel,
  • Lynne M. Gignac,
  • Eric A. Joseph,
  • Satyavolu Papa Rao,
  • Gustavo Stolovitzky,
  • Stanislav Polonsky,
  • Qinghuang Lin

DOI
https://doi.org/10.1038/ncomms14243
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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The wide use of microfluidics for biological analysis demands scalable preparation methods, yet in practice it is very challenging. Here, Wanget al. show a wafer-scale fabrication of nanofluidic chips with single-digit nanometre dimension, which is compatible with standard semiconductor processing.