Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of
<i>Vibrio cholerae</i>
O-Specific Polysaccharide-Specific Monoclonal Antibodies
Robert C. Kauffman,
Oluwaseyi Adekunle,
Hanyi Yu,
Alice Cho,
Lindsay E. Nyhoff,
Meagan Kelly,
Jason B. Harris,
Taufiqur Rahman Bhuiyan,
Firdausi Qadri,
Stephen B. Calderwood,
Richelle C. Charles,
Edward T. Ryan,
Jun Kong,
Jens Wrammert
Affiliations
Robert C. Kauffman
Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Oluwaseyi Adekunle
Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Hanyi Yu
Department of Computer Science, Emory University, Atlanta, Georgia, USA
Alice Cho
Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Lindsay E. Nyhoff
Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Meagan Kelly
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Jason B. Harris
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Taufiqur Rahman Bhuiyan
Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Firdausi Qadri
Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Stephen B. Calderwood
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Immunity to the severe diarrheal disease cholera is largely mediated by lipopolysaccharide (LPS)-specific antibodies. However, the properties and protective mechanism of functionally relevant antibodies have not been well defined.
