SENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGION

Abstract

Study of sensitization spread is crucial to the understanding of formation mechanisms of allergic diseases symptoms and development of prevention programs. However, this parameter has been studied very insufficiently in Russia. The aim of this trial is to study spread of sensitization to allergens and skin sensitivity to histamine in the populations of urban and rural schoolchildren using the method of skin prick test. Methods: the authors examined 2,290 urban and rural schoolchildren (1-11 grades). Mixed allergens of house dust mites, cockroach, fish, birch pollen, mixed weeds and cat hair were used for the allergy test. Results: the authors revealed spread of sensitization to various allergens in various age-sex groups of urban and rural schoolchildren in Tomsk Region. Conclusion: the trial revealed that sensitization spread and skin sensitivity to histamine was higher in urban schoolchildren than in their rural peers (p<0.001). Lower sensitization spread index in rural schoolchildren may be caused the skin reactivity reduction.

Keywords

• children
• sensitization
• spread