Black phosphorus nanosheets and paclitaxel encapsulated hydrogel for synergistic photothermal-chemotherapy
Sang Shoushan,
Jiang Zhipeng,
Xie Ning,
Rao Huaxin,
Liao Kedan,
Hu Qinqin,
Zhang Ziyong,
Guo Rui,
Fan Taojian,
Deng Kaixian
Affiliations
Sang Shoushan
Department of Material Science and Engineering, Jinan University, Guangzhou510632, China
Jiang Zhipeng
Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, China
Xie Ning
Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan528308, China
Rao Huaxin
Department of Material Science and Engineering, Jinan University, Guangzhou510632, China
Liao Kedan
Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan528308, China
Hu Qinqin
Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan528308, China
Zhang Ziyong
Department of Material Science and Engineering, Jinan University, Guangzhou510632, China
Guo Rui
Department of Material Science and Engineering, Jinan University, Guangzhou510632, China
Fan Taojian
Institute of Microscale Optoelectronics, Collaborative Innovation Centre for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Shenzhen University, Shenzhen518060, China
Deng Kaixian
Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde), Foshan528308, China
Gastric cancer treatment remains a major challenge because of its aggressiveness and spread. In this study, we developed a hydrogel system for the treatment of gastric cancer, which can kill tumor cells through photothermal action and drug treatment. Based on the formation of Schiff base linkage, the OSA/AHA/BP/PTX hydrogel was prepared by mixing oxidized sodium alginate (OSA), aminated hyaluronic acid (AHA), black phosphorus (BP), and paclitaxel (PTX) under physiological conditions, which exhibited excellent photothermal effect and slow release ability PTX. Moreover, CCK-8 and live/dead fluorescent confirmed that OSA/AHA/BP/PTX hydrogel could obvious inhibition the proliferation of gastric cancer cells (SGC7901). More importantly, in vivo experiments further show that the prepared hydrogel can significantly improve the tumor treatment effect of tumor-bearing mice by inducing tumor cell apoptosis and inhibiting the proliferation of new tumor cells. Compared with chemotherapy alone, photothermal combined chemotherapy had a better antitumor effect. The results of this study indicate that the composite hydrogel with controlled release of paclitaxel can be used as a candidate material for cancer treatment.
