HardwareX
(Sep 2024)
Design and construction of a low-cost compressive loading and perfusion flow bioreactor
Alexis Graham,
Charlotte Thompson,
Darrock Flynn,
Honor Elchos,
Jaydon Gibson,
Lauren B. Priddy,
Matthew W. Priddy
Affiliations
Alexis Graham
Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Charlotte Thompson
Department of Mechanical Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Darrock Flynn
Department of Mechanical Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Honor Elchos
Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Jaydon Gibson
Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Lauren B. Priddy
Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America
Matthew W. Priddy
Department of Mechanical Engineering, Mississippi State University, Mississippi State, MS 39762, United States of America; Corresponding author.
Journal volume & issue
Vol. 19
Abstract
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This article reports the design and construction of an open-source compressive loading and perfusion flow bioreactor for under $4000, as well as validation of the device and an example use-application. The bioreactor is capable of recording applied force and displacement as well as regulating media flow rate. This bioreactor was built to be user friendly, widely adaptable for modular changes, and made of readily available materials.
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