Nature Communications (Oct 2017)

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

  • Matthew J. Smith,
  • Elizabeth Ottoni,
  • Noboru Ishiyama,
  • Marilyn Goudreault,
  • André Haman,
  • Claus Meyer,
  • Monika Tucholska,
  • Genevieve Gasmi-Seabrook,
  • Serena Menezes,
  • Rob C. Laister,
  • Mark D. Minden,
  • Rolf Marschalek,
  • Anne-Claude Gingras,
  • Trang Hoang,
  • Mitsuhiko Ikura

DOI
https://doi.org/10.1038/s41467-017-01326-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.