Exo-selective intermolecular Diels–Alder reaction by PyrI4 and AbnU on non-natural substrates

Rajnandani Kashyap; Naga Veera Yerra; Joachyutharayalu Oja; Sandeepchowdary Bala; Gal Reddy Potuganti; Jagadeshwar Reddy Thota; Manjula Alla; Debnath Pal; Anthony Addlagatta

doi:10.1038/s42004-021-00552-9

Communications Chemistry (Aug 2021)

Exo-selective intermolecular Diels–Alder reaction by PyrI4 and AbnU on non-natural substrates

Rajnandani Kashyap,
Naga Veera Yerra,
Joachyutharayalu Oja,
Sandeepchowdary Bala,
Gal Reddy Potuganti,
Jagadeshwar Reddy Thota,
Manjula Alla,
Debnath Pal,
Anthony Addlagatta

Affiliations

Rajnandani Kashyap: Department of Applied Biology, CSIR-Indian Institute of Chemical Technology
Naga Veera Yerra: Academy of Scientific and Innovative Research (AcSIR)
Joachyutharayalu Oja: Fluoro-Agrochemicals Department, CSIR-Indian Institute of Chemical Technology
Sandeepchowdary Bala: Department of Applied Biology, CSIR-Indian Institute of Chemical Technology
Gal Reddy Potuganti: Academy of Scientific and Innovative Research (AcSIR)
Jagadeshwar Reddy Thota: Academy of Scientific and Innovative Research (AcSIR)
Manjula Alla: Academy of Scientific and Innovative Research (AcSIR)
Debnath Pal: Department of Computational and Data Sciences, Indian Institute of Science
Anthony Addlagatta: Department of Applied Biology, CSIR-Indian Institute of Chemical Technology

DOI: https://doi.org/10.1038/s42004-021-00552-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

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Diels-Alderases remain rare in nature, particularly those catalysing intermolecular reactions. Here two natural Diels-Alderases are shown to catalyse exo-selective intermolecular Diels-Alder reactions on non-natural substrates.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

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