Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery
Catalina Paula Spatarelu,
Anita-Laura (Radu) Chiriac,
Bogdan Cursaru,
Tanta-Verona Iordache,
Ana-Mihaela Gavrila,
Crina-Thea Cojocaru,
Razvan-Edward Botez,
Bogdan Trica,
Andrei Sarbu,
Mircea Teodorescu,
Vlad Tofan,
Francois-Xavier Perrin,
Anamaria Zaharia
Affiliations
Catalina Paula Spatarelu
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Anita-Laura (Radu) Chiriac
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Bogdan Cursaru
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Tanta-Verona Iordache
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Ana-Mihaela Gavrila
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Crina-Thea Cojocaru
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Razvan-Edward Botez
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Bogdan Trica
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Andrei Sarbu
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
Mircea Teodorescu
Department of Bioresources and Polymer Science, Faculty of Applied Chemistry and Materials Science, University “Politehnica” of Bucharest, 1–7 Gh. Polizu Street, 1st District, 011061 Bucharest, Romania
Vlad Tofan
Cantacuzino National Institute of Research-Development for Microbiology and Immunology (CNIR), 103 Spl. Independenţei, 5th District, 011061 Bucharest, Romania
Francois-Xavier Perrin
MAPIEM Laboratory, University of Toulon, EA 4323, 83130 La Garde, France
Anamaria Zaharia
Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania
This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite−nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.
