Severe Jarisch-Herxheimer Reaction (JHR) in a leptospirosis patient: A case report
Ruo-Yan Zhao,
Meng-Die Liu,
Ying-Xin Lin,
Lei Huang
Affiliations
Ruo-Yan Zhao
Hubei University of Medicine, Shiyan, 442000, Hubei Province, China; Intensive Care Unit, Peking University Shenzhen Hospital, Shenzhen, 518000, Guangdong Province, China
Meng-Die Liu
Shenzhen University, Shenzhen, 518000, Guangdong Province, China; Intensive Care Unit, Peking University Shenzhen Hospital, Shenzhen, 518000, Guangdong Province, China
Ying-Xin Lin
Intensive Care Unit, Peking University Shenzhen Hospital, Shenzhen, 518000, Guangdong Province, China
Lei Huang
Intensive Care Unit, Peking University Shenzhen Hospital, Shenzhen, 518000, Guangdong Province, China; Corresponding author. Intensive Care Unit, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Futian District, Shenzhen, Shenzhen, 518000, Guangdong Province, China.
Leptospirosis is a zoonosis that is related to potential respiratory, renal, neurological, and cardiovascular failure. At present, antibiotics are the recommended treatment, but due to the underlying cause of the disease, they may induce the Jarisch-Herxheimer reaction (JHR) within 24 hours. At the same time, we speculate that JHR may aggravate the natural course of leptospirosis. Considering that there are few available reports on this event, we will share a case of pulmonary hemorrhagic leptospirosis, where antibiotic treatment is suspected to have triggered the JHR. This report is expected to improve clinical attention to the relationship between leptospirosis and JHR.
