Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan

Peter K. Joshi; Krista Fischer; Katharina E. Schraut; Harry Campbell; Tõnu Esko; James F. Wilson

doi:10.1038/ncomms11174

Nature Communications (Mar 2016)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan

Peter K. Joshi,
Krista Fischer,
Katharina E. Schraut,
Harry Campbell,
Tõnu Esko,
James F. Wilson

Affiliations

Peter K. Joshi: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Krista Fischer: Estonian Genome Center, University of Tartu
Katharina E. Schraut: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Harry Campbell: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Tõnu Esko: Estonian Genome Center, University of Tartu
James F. Wilson: Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh

DOI: https://doi.org/10.1038/ncomms11174
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

Read online

Understanding the genetic influences on human aging requires a large number of subjects for a study of sufficient power. Here, Jim Wilson and colleagues use information on parental ages at death to show that common variants near the genes for apolipoprotein E and nicotinic acetylcholine receptor subunit alpha 5 are associated with longer lifespan.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal