Nature Communications (Apr 2018)

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

  • Yohei Abe,
  • Yosuke Fujiwara,
  • Hiroki Takahashi,
  • Yoshihiro Matsumura,
  • Tomonobu Sawada,
  • Shuying Jiang,
  • Ryo Nakaki,
  • Aoi Uchida,
  • Noriko Nagao,
  • Makoto Naito,
  • Shingo Kajimura,
  • Hiroshi Kimura,
  • Timothy F. Osborne,
  • Hiroyuki Aburatani,
  • Tatsuhiko Kodama,
  • Takeshi Inagaki,
  • Juro Sakai

DOI
https://doi.org/10.1038/s41467-018-03868-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.