Frontiers in Science (Apr 2024)
Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation
- Ioana Agache,
- Cezmi Akdis,
- Cezmi Akdis,
- Mubeccel Akdis,
- Ali Al-Hemoud,
- Isabella Annesi-Maesano,
- Isabella Annesi-Maesano,
- John Balmes,
- John Balmes,
- Lorenzo Cecchi,
- Athanasios Damialis,
- Tari Haahtela,
- Adam L. Haber,
- Jaime E. Hart,
- Jaime E. Hart,
- Marek Jutel,
- Marek Jutel,
- Yasutaka Mitamura,
- Blandina T. Mmbaga,
- Blandina T. Mmbaga,
- Jae-Won Oh,
- Abbas Ostadtaghizadeh,
- Ruby Pawankar,
- Mary Prunicki,
- Harald Renz,
- Harald Renz,
- Harald Renz,
- Mary B. Rice,
- Nelson Augusto Rosario Filho,
- Vanitha Sampath,
- Chrysanthi Skevaki,
- Chrysanthi Skevaki,
- Francis Thien,
- Claudia Traidl-Hoffmann,
- Claudia Traidl-Hoffmann,
- Claudia Traidl-Hoffmann,
- Gary W. K. Wong,
- Kari C. Nadeau
Affiliations
- Ioana Agache
- Faculty of Medicine, Allergy and Clinical Immunology, Transilvania University of Brasov, Brasov, Romania
- Cezmi Akdis
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
- Cezmi Akdis
- Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
- Mubeccel Akdis
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
- Ali Al-Hemoud
- Crisis Decision Support Program, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, Safat, Kuwait
- Isabella Annesi-Maesano
- Institute Debrest of Epidemiology and Public Health, UMR1318 INSERM and Montpellier University, Montpellier, France
- Isabella Annesi-Maesano
- Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France
- John Balmes
- Department of Medicine, University of California, San Francisco, San Francisco, CA, United States
- John Balmes
- School of Public Health, University of California at Berkeley, Berkeley, CA, United States
- Lorenzo Cecchi
- SOS Allergy and Clinical Immunology, USL Toscana Centro, Prato, Italy
- Athanasios Damialis
- 0Terrestrial Ecology and Climate Change, Department of Ecology, School of Biology, Faculty of Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
- Tari Haahtela
- 1Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
- Adam L. Haber
- 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States
- Jaime E. Hart
- 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States
- Jaime E. Hart
- 3Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
- Marek Jutel
- 4Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland
- Marek Jutel
- 5ALL-MED Medical Research Institute, Wroclaw, Poland
- Yasutaka Mitamura
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
- Blandina T. Mmbaga
- 6Department of Pediatrics, Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
- Blandina T. Mmbaga
- 7Kilimanjaro Christian Medical University College, Moshi, Tanzania
- Jae-Won Oh
- 8Department of Pediatrics, Hanyang University College of Medicine, Seoul, Republic of Korea
- Abbas Ostadtaghizadeh
- 9Department of Health in Emergencies and Disasters, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
- Ruby Pawankar
- 0Department of Pediatrics, Nippon Medical School, Tokyo, Japan
- Mary Prunicki
- 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States
- Harald Renz
- 7Kilimanjaro Christian Medical University College, Moshi, Tanzania
- Harald Renz
- 1Institute of Laboratory Medicine and Pathobiochemistry, Philipps-University Marburg, Marburg, Germany
- Harald Renz
- 2Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany
- Mary B. Rice
- 3Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
- Nelson Augusto Rosario Filho
- 4Department of Pediatrics, Federal University of Parana, Curitiba, Brazil
- Vanitha Sampath
- 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States
- Chrysanthi Skevaki
- 1Institute of Laboratory Medicine and Pathobiochemistry, Philipps-University Marburg, Marburg, Germany
- Chrysanthi Skevaki
- 2Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany
- Francis Thien
- 5Department of Respiratory Medicine, Eastern Health & Monash University, Melbourne, VIC, Australia
- Claudia Traidl-Hoffmann
- 6Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
- Claudia Traidl-Hoffmann
- 7Institute of Environmental Medicine, Helmholtz Center Munich, German Research Center for Environmental Health, Augsburg, Germany
- Claudia Traidl-Hoffmann
- Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
- Gary W. K. Wong
- 8Department of Pediatrics, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China
- Kari C. Nadeau
- 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States
- DOI
- https://doi.org/10.3389/fsci.2024.1279192
- Journal volume & issue
-
Vol. 2
Abstract
Global warming and climate change have increased the pollen burden and the frequency and intensity of wildfires, sand and dust storms, thunderstorms, and heatwaves—with concomitant increases in air pollution, heat stress, and flooding. These environmental stressors alter the human exposome and trigger complex immune responses. In parallel, pollutants, allergens, and other environmental factors increase the risks of skin and mucosal barrier disruption and microbial dysbiosis, while a loss of biodiversity and reduced exposure to microbial diversity impairs tolerogenic immune development. The resulting immune dysregulation is contributing to an increase in immune-mediated diseases such as asthma and other allergic diseases, autoimmune diseases, and cancer. It is now abundantly clear that multisectoral, multidisciplinary, and transborder efforts based on Planetary Health and One Health approaches (which consider the dependence of human health on the environment and natural ecosystems) are urgently needed to adapt to and mitigate the effects of climate change. Key actions include reducing emissions and improving air quality (through reduced fossil fuel use), providing safe housing (e.g., improving weatherization), improving diets (i.e., quality and diversity) and agricultural practices, and increasing environmental biodiversity and green spaces. There is also a pressing need for collaborative, multidisciplinary research to better understand the pathophysiology of immune diseases in the context of climate change. New data science techniques, biomarkers, and economic models should be used to measure the impact of climate change on immune health and disease, to inform mitigation and adaptation efforts, and to evaluate their effectiveness. Justice, equity, diversity, and inclusion (JEDI) considerations should be integral to these efforts to address disparities in the impact of climate change.
Keywords
