Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Nan W. Hultgren; Jennifer S. Fang; Mary E. Ziegler; Ricardo N. Ramirez; Duc T. T. Phan; Michaela M. S. Hatch; Katrina M. Welch-Reardon; Antonio E. Paniagua; Lin S. Kim; Nathan N. Shon; David S. Williams; Ali Mortazavi; Christopher C. W. Hughes

doi:10.1038/s41467-020-18633-z

Nature Communications (Oct 2020)

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Nan W. Hultgren,
Jennifer S. Fang,
Mary E. Ziegler,
Ricardo N. Ramirez,
Duc T. T. Phan,
Michaela M. S. Hatch,
Katrina M. Welch-Reardon,
Antonio E. Paniagua,
Lin S. Kim,
Nathan N. Shon,
David S. Williams,
Ali Mortazavi,
Christopher C. W. Hughes

Affiliations

Nan W. Hultgren: The Department of Molecular Biology and Biochemistry, University of California Irvine
Jennifer S. Fang: The Department of Molecular Biology and Biochemistry, University of California Irvine
Mary E. Ziegler: The Department of Molecular Biology and Biochemistry, University of California Irvine
Ricardo N. Ramirez: The Department of Developmental and Cell Biology, University of California Irvine
Duc T. T. Phan: The Department of Molecular Biology and Biochemistry, University of California Irvine
Michaela M. S. Hatch: The Department of Molecular Biology and Biochemistry, University of California Irvine
Katrina M. Welch-Reardon: The Department of Molecular Biology and Biochemistry, University of California Irvine
Antonio E. Paniagua: The Department of Ophthalmology, University of California, Los Angeles
Lin S. Kim: The Department of Molecular Biology and Biochemistry, University of California Irvine
Nathan N. Shon: The Department of Molecular Biology and Biochemistry, University of California Irvine
David S. Williams: The Department of Ophthalmology, University of California, Los Angeles
Ali Mortazavi: The Department of Developmental and Cell Biology, University of California Irvine
Christopher C. W. Hughes: The Department of Molecular Biology and Biochemistry, University of California Irvine

DOI: https://doi.org/10.1038/s41467-020-18633-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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