Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Abstract

Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.