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Ganglioglial differentiation in a medulloblastoma with extensive nodularity

Jornal Brasileiro de Patologia e Medicina Laboratorial. 2013;49(6):433-436 DOI 10.1590/S1676-24442013000600009


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Journal Title: Jornal Brasileiro de Patologia e Medicina Laboratorial

ISSN: 1676-2444 (Print); 1678-4774 (Online)

Publisher: Sociedade Brasileira de Patologia Clínica

Society/Institution: Sociedade Brasileira de Patologia Clínica

LCC Subject Category: Medicine: Pathology

Country of publisher: Brazil

Language of fulltext: English

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Bruna Ferreira Bernert (Universidade Federal do Paraná)

Alex Roman (Hospital Pequeno Príncipe)

Paulo Carboni Jr. (Hospital Pequeno Príncipe)

Luiz Fernando Bleggi Torres (Universidade Federal do Paraná)


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Time From Submission to Publication: 20 weeks


Abstract | Full Text

We report the case of a 2 month-old patient with a large, probably congenital, posterior fossa tumor. Hematoxylin and eosin staining (HE), reticulin and immunohistochemistry revealed a medulloblastoma with extensive nodularity, showing ganglioglial differentiation, high proliferative index in the primitive neuroectodermal tumor (PNET) area and low proliferative index in the ganglioglial maturation area. Ganglioglial differentiation is a rare event in medulloblastomas and its mechanism is still unknown. Previous surgery, radiation and chemotherapy may contribute to differentiation in astrocytic and nerve cells. In this case, however, the differentiation was already present in the first specimen, prior to any surgical or therapeutic procedure.