Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Klára Kirsch; András Zeke; Orsolya Tőke; Péter Sok; Ashish Sethi; Anna Sebő; Ganesan Senthil Kumar; Péter Egri; Ádám L. Póti; Paul Gooley; Wolfgang Peti; Isabel Bento; Anita Alexa; Attila Reményi

doi:10.1038/s41467-020-19582-3

Nature Communications (Nov 2020)

Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Klára Kirsch,
András Zeke,
Orsolya Tőke,
Péter Sok,
Ashish Sethi,
Anna Sebő,
Ganesan Senthil Kumar,
Péter Egri,
Ádám L. Póti,
Paul Gooley,
Wolfgang Peti,
Isabel Bento,
Anita Alexa,
Attila Reményi

Affiliations

Klára Kirsch: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
András Zeke: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Orsolya Tőke: Laboratory for NMR Spectroscopy, Research Center for Natural Sciences
Péter Sok: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Ashish Sethi: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Anna Sebő: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Ganesan Senthil Kumar: Department of Chemistry and Biochemistry, University of Arizona
Péter Egri: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Ádám L. Póti: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Paul Gooley: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Wolfgang Peti: Department of Chemistry and Biochemistry, University of Arizona
Isabel Bento: European Molecular Biology Laboratory
Anita Alexa: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences
Attila Reményi: Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences

DOI: https://doi.org/10.1038/s41467-020-19582-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphorylation, thereby modulating ATF2’s sensitivity to the JNK and p38 pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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