Nature Communications (Sep 2019)

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

  • Patrick L. Leslie,
  • Yvonne L. Chao,
  • Yi-Hsuan Tsai,
  • Subrata K. Ghosh,
  • Alessandro Porrello,
  • Amanda E. D. Van Swearingen,
  • Emily B. Harrison,
  • Brian C. Cooley,
  • Joel S. Parker,
  • Lisa A. Carey,
  • Chad V. Pecot

DOI
https://doi.org/10.1038/s41467-019-12222-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and therefore suggest caution with HDAC inhibitors.