Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Alex S. Hartlage; Satyapramod Murthy; Arvind Kumar; Sheetal Trivedi; Piyush Dravid; Himanshu Sharma; Christopher M. Walker; Amit Kapoor

doi:10.1038/s41467-019-09105-0

Nature Communications (Mar 2019)

Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection

Alex S. Hartlage,
Satyapramod Murthy,
Arvind Kumar,
Sheetal Trivedi,
Piyush Dravid,
Himanshu Sharma,
Christopher M. Walker,
Amit Kapoor

Affiliations

Alex S. Hartlage: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Satyapramod Murthy: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Arvind Kumar: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Sheetal Trivedi: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Piyush Dravid: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Himanshu Sharma: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Christopher M. Walker: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital
Amit Kapoor: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital

DOI: https://doi.org/10.1038/s41467-019-09105-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Development of a HCV vaccine is hampered by a lack of appropriate small animal models. Here, Hartlage et al. describe a rat model of hepacivirus persistence and show that persistence can be prevented by vaccination with viral non-structural proteins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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