Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice

Byoung Chul Kim; Tae-Jin Kang; Song Hou Jin; Se-Kon Kim; Seong-Boem Lee; Gue-Tae Chae

doi:10.1080/09629350410001664734

Mediators of Inflammation (Jan 2004)

Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice

Byoung Chul Kim,
Tae-Jin Kang,
Song Hou Jin,
Se-Kon Kim,
Seong-Boem Lee,
Gue-Tae Chae

Affiliations

Byoung Chul Kim: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea
Tae-Jin Kang: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea
Song Hou Jin: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea
Se-Kon Kim: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea
Seong-Boem Lee: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea
Gue-Tae Chae: Institute of Hansen’s Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-Gu, Seoul 137-701, South Korea

DOI: https://doi.org/10.1080/09629350410001664734
Journal volume & issue: Vol. 13, no. 1
pp. 51 – 52

Abstract

Read online

RIPK 2 is adapter molecule in the signal pathway involved in Toll-like receptors. However, there has been no reported association between receptor-interacting serine/threonine kinase 2 (RIPK 2) expression and the infectious diseases involving mycobacterial infection. This study found that its expression was down-regulated in the footpads and skin but was up-regulated in the liver of Mycobacterium leprae-infected nu/nu mice compared with those of the M. leprae non-infected nu/nu mice. It was observed that the interlukin-12p40 and interferon-γ genes involved in the susceptibility of M. leprae were down-regulated in the skin but were up-regulated in the liver. Overall, this suggests that regulation of RIPK 2 expression is tissue-specifically associated with M. leprae infection.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal

Abstract

Keywords