Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET/CT

Joyce van Sluis; Ronald Borra; Charalampos Tsoumpas; Johannes H. van Snick; Mostafa Roya; Dik ten Hove; Adrienne H. Brouwers; Adriaan A. Lammertsma; Walter Noordzij; Rudi A.J.O. Dierckx; Riemer H.J.A. Slart; Andor W.J.M. Glaudemans

doi:10.1186/s40644-022-00507-w

Cancer Imaging (Dec 2022)

Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET/CT

Joyce van Sluis,
Ronald Borra,
Charalampos Tsoumpas,
Johannes H. van Snick,
Mostafa Roya,
Dik ten Hove,
Adrienne H. Brouwers,
Adriaan A. Lammertsma,
Walter Noordzij,
Rudi A.J.O. Dierckx,
Riemer H.J.A. Slart,
Andor W.J.M. Glaudemans

Affiliations

Joyce van Sluis: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Ronald Borra: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Charalampos Tsoumpas: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Johannes H. van Snick: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Mostafa Roya: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Dik ten Hove: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Adrienne H. Brouwers: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Adriaan A. Lammertsma: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Walter Noordzij: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Rudi A.J.O. Dierckx: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Riemer H.J.A. Slart: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen
Andor W.J.M. Glaudemans: Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen

DOI: https://doi.org/10.1186/s40644-022-00507-w
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 11

Abstract

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Abstract This review describes the main benefits of using long axial field of view (LAFOV) PET in clinical applications. As LAFOV PET is the latest development in PET instrumentation, many studies are ongoing that explore the potentials of these systems, which are characterized by ultra-high sensitivity. This review not only provides an overview of the published clinical applications using LAFOV PET so far, but also provides insight in clinical applications that are currently under investigation. Apart from the straightforward reduction in acquisition times or administered amount of radiotracer, LAFOV PET also allows for other clinical applications that to date were mostly limited to research, e.g., dual tracer imaging, whole body dynamic PET imaging, omission of CT in serial PET acquisition for repeat imaging, and studying molecular interactions between organ systems. It is expected that this generation of PET systems will significantly advance the field of nuclear medicine and molecular imaging.

Published in Cancer Imaging

ISSN: 1740-5025 (Print); 1470-7330 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://cancerimagingjournal.biomedcentral.com

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