Annals of Pediatric Endocrinology & Metabolism (Sep 2017)

A rare case of multiple pituitary adenomas in an adolescent Cushing disease presenting as a vertebral compression fracture

  • Ji-Yeon Song,
  • Sue-Jean Mun,
  • Soon-Ki Sung,
  • Jae-Yeon Hwang,
  • Seung-Kug Baik,
  • Jee Yeon Kim,
  • Chong-Kun Cheon,
  • Su-Young Kim,
  • Yoo-Mi Kim

DOI
https://doi.org/10.6065/apem.2017.22.3.197
Journal volume & issue
Vol. 22, no. 3
pp. 197 – 202

Abstract

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Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain, short stature, headache, and hypertension. On magnetic resonance imaging (MRI), only a left pituitary microadenoma was found. After surgery, transient clinical improvement was observed but headache and hypertension were observed again after 3 months later. Follow-up MRI showed a newly developed right pituitary microadenoma 6 months after the surgery. The need for careful clinical and radiographic follow-up should be emphasized in the search for potential MPAs in patients with persistent Cushing disease.

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