ADAM8 inactivation retards intervertebral disc degeneration in mice

• Zuozhen Tian,
• Frances S. Shofer,
• Mingyue Fan,
• Alec Z. Sandroni,
• Lutian Yao,
• Lin Han,
• Ling Qin,
• Motomi Enomoto-Iwamoto,
• Yejia Zhang

Affiliations

Zuozhen Tian

Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA

Frances S. Shofer

Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Mingyue Fan

School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104, USA

Alec Z. Sandroni

Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA

Lutian Yao

Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Orthopedics/Sports Medicine and Joint Surgery, the First Hospital of China Medical University, Shenyang, Liaoning 110001, China

Lin Han

School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104, USA

Ling Qin

Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Motomi Enomoto-Iwamoto

Department of Orthopedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Yejia Zhang

Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA; Department of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Section of Rehabilitation Medicine, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA; Corresponding author. Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.