Role of quantitative diffusion-weighted imaging in differentiation between red and infiltrated marrow in pediatric patients with hematologic malignancy

Abstract

Abstract Background To evaluate the role of DWI with ADC value measurement in the differentiation between bone marrow infiltration and normal red marrow in pediatric patients with hematologic malignancies Results Significant results were obtained between ADC values of normal red and infiltrated marrow (p < 0.005). ADC values were significantly lower in infiltrative marrow lesions. The cutoff ADC value for benign and malignant lesions was 0.612 × 10−3 mm2/s. Conclusion DWI with ADC value has an additive role in differentiation between infiltrative lesions from foci of red marrow in patients with hematological malignancies.

Keywords

• Hematologic malignancy
• Leukemia
• Lymphoma
• Diffusion-weighted imaging (DWI)
• Apparent diffusion coefficient (ADC)
• Marrow infiltration