P429: THERAPY-INDUCED SENESCENCE TRIGGERS UPREGULATION OF ANTIGEN PRESENTATION VIA PRC2 INHIBITION AND PROMOTES ANTI-TUMOUR IMMUNITY IN ACUTE MYELOID LEUKAEMIA

• Diego Gilioli,
• Simona Fusco,
• Teresa Tavella,
• Kety Giannetti,
• Anastasia Conti,
• Santoro Antonella,
• Edoardo Carsana,
• Stefano Beretta,
• Martin Schönlein,
• Valentina Gambacorta,
• Federico Aletti,
• Matteo Giovanni Carrabba,
• Chiara Bonini,
• Fabio Ciceri,
• Ivan Merelli,
• Luca Vago,
• Clemens A. Schmitt,
• Raffaella DI Micco

Affiliations

Diego Gilioli

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Simona Fusco

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Teresa Tavella

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Kety Giannetti

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Anastasia Conti

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Santoro Antonella

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Edoardo Carsana

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy

Stefano Beretta

2 National Research Council, Institute for Biomedical Technologies, Segrate, Italy

Martin Schönlein

4 Charité - Universitätsmedizin, Medical Department of Hematology, Oncology and Tumor Immunology, Berlin, Germany

Valentina Gambacorta

5 IRCCS San Raffaele Scientific Institute, Milano, Italy, Unit of Immunogenetics, Leukaemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, Milan, Italy

Federico Aletti

6 IRCCS San Raffaele Scientific Institute, Hematology and Bone Marrow Transplantation Unit, Milan, Italy

Matteo Giovanni Carrabba

6 IRCCS San Raffaele Scientific Institute, Hematology and Bone Marrow Transplantation Unit, Milan, Italy

Chiara Bonini

7 IRCCS San Raffaele Scientific Institute, Unit of Experimental Hematology, Division of Immunology, Transplantation and Infectious Disease, Milan, Italy

Fabio Ciceri

6 IRCCS San Raffaele Scientific Institute, Hematology and Bone Marrow Transplantation Unit, Milan, Italy

Ivan Merelli

2 National Research Council, Institute for Biomedical Technologies, Segrate, Italy

Luca Vago

5 IRCCS San Raffaele Scientific Institute, Milano, Italy, Unit of Immunogenetics, Leukaemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, Milan, Italy

Clemens A. Schmitt

4 Charité - Universitätsmedizin, Medical Department of Hematology, Oncology and Tumor Immunology, Berlin, Germany

Raffaella DI Micco

1 San Raffaele Hospital, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy