Single-molecule characterization of subtype-specific β1 integrin mechanics

Myung Hyun Jo; Jing Li; Valentin Jaumouillé; Yuxin Hao; Jessica Coppola; Jiabin Yan; Clare M. Waterman; Timothy A. Springer; Taekjip Ha

doi:10.1038/s41467-022-35173-w

Nature Communications (Dec 2022)

Single-molecule characterization of subtype-specific β1 integrin mechanics

Myung Hyun Jo,
Jing Li,
Valentin Jaumouillé,
Yuxin Hao,
Jessica Coppola,
Jiabin Yan,
Clare M. Waterman,
Timothy A. Springer,
Taekjip Ha

Affiliations

Myung Hyun Jo: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University
Jing Li: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Valentin Jaumouillé: Cell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health
Yuxin Hao: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Jessica Coppola: Institute for Protein Innovation Harvard Institutes of Medicine
Jiabin Yan: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Clare M. Waterman: Cell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health
Timothy A. Springer: Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Taekjip Ha: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-022-35173-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Integrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton architectures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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