Nature Communications (Jan 2023)
Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8
- Hang Yin,
- Jian Zheng,
- Qiuqiu He,
- Xuan Zhang,
- Xuzichao Li,
- Yongjian Ma,
- Xiao Liang,
- Jiaqi Gao,
- Benjamin L. Kocsis,
- Zhuang Li,
- Xiang Liu,
- Neal M. Alto,
- Long Li,
- Heng Zhang
Affiliations
- Hang Yin
- The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Haihe Laboratory of Cell Ecosystem, Tianjin Institute of Immunology, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University
- Jian Zheng
- The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Haihe Laboratory of Cell Ecosystem, Tianjin Institute of Immunology, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University
- Qiuqiu He
- The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Haihe Laboratory of Cell Ecosystem, Tianjin Institute of Immunology, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University
- Xuan Zhang
- Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Xuzichao Li
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University
- Yongjian Ma
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University
- Xiao Liang
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University
- Jiaqi Gao
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University
- Benjamin L. Kocsis
- Department of Microbiology, University of Texas Southwestern Medical Center
- Zhuang Li
- State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University
- Xiang Liu
- State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University
- Neal M. Alto
- Department of Microbiology, University of Texas Southwestern Medical Center
- Long Li
- The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Haihe Laboratory of Cell Ecosystem, Tianjin Institute of Immunology, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University
- Heng Zhang
- The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Haihe Laboratory of Cell Ecosystem, Tianjin Institute of Immunology, Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University
- DOI
- https://doi.org/10.1038/s41467-022-35725-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
The multifunctional GSDMB protein is an important molecule in human immunity. Here, the authors decipher the molecular mechanisms of GSDMB targeting by the bacterial virulence factor IpaH7.8 and provide insights into GSDMB-mediated pyroptosis.
