New thiopyrano[2,3-d][1,3]thiazole derivatives as potential antiviral agents

Abstract

A series of novel thiopyrano[2,3-d][1,3]thiazole derivatives were synthesized and evaluated for their antiviral activity in vitro within AACF NIAID programme. Compounds were studied towards Dengue Virus Type 2, Venezuelan Equine Encephalitis Virus, Respiratory Syncytial Virus, SARS Coronavirus, Rift Valley Fever Virus, Tacaribe Virus, Influenza Virus Types A and B. Among the tested thiopyrano[2,3-d][1,3]thiazoles, alkyl rel-(5R,5aR,11bS)-2,6-dioxo-3,5a,6,11b-tetrahydro-2Н,5H-chromeno[4’,3’:4,5]thiopyrano[2,3-d][1,3]thiazole-5-carboxylates 8 and 11 were found to be the most active and showed significant antiviral activity against Influenza Virus Types A H3N2 and H5N1.