eJHaem (Feb 2024)

Novel BRAF N581S mutation in mantle cell lymphoma

  • Nisha Hariharan,
  • Davsheen Bedi,
  • Michael Y. Choi,
  • Huan‐You Wang,
  • Benjamin M. Heyman

DOI
https://doi.org/10.1002/jha2.847
Journal volume & issue
Vol. 5, no. 1
pp. 247 – 250

Abstract

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Abstract BRAF mutations are associated with a small number of hematologic malignancies, including hairy cell leukemia and histiocytic disorders. In addition, BRAF mutations have also been detected in low frequency in other B‐cell lymphomas, such as chronic lymphocytic leukemia and diffuse large B‐cell lymphoma, but never in mantle cell lymphoma (MCL). We present a case of a 69‐year‐old female with classic MCL harboring a BRAFN581S mutation. To our knowledge, this is the first reported case of any BRAF mutation in MCL.

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