PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity

• Tianbai Zhong,
• Xiuyun Sun,
• Li Yu,
• Yongbo Liu,
• Xin Lin,
• Yu Rao,
• Wei Wu

Affiliations

Tianbai Zhong

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University

Xiuyun Sun

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University

Li Yu

Institute for Immunology and School of Medicine, Tsinghua University

Yongbo Liu

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University

Xin Lin

Institute for Immunology and School of Medicine, Tsinghua University

Yu Rao

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University

Wei Wu

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University